When More Is Less: Dual Phosphorylation Protects Signaling Off State against Overexpression
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چکیده
منابع مشابه
When Less is More
engine and airframe manufacturers for decades have cited the direct relationship between engine wear and high exhaust gas temperature (EGT) in recommending that operators use less than maximum takeoff thrust whenever possible. While the cost benefits of reduced-thrust takeoffs are thoroughly documented, the safety benefits are not as well understood. Thus, there is a common perception that usin...
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I N THIS issue of ANESTHESIOLOGY, Li et al. 1 report on a laboratory study of resuscitation from uncontrolled hemorrhagic shock in rats. For those who have not followed this topic in the trauma literature, the results might seem counterintuitive—even heretical. Resuscitate to a lower blood pressure? How could that possibly be better? Although the physiologic reasons for this enigmatic effect ar...
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It has been suggested that external and/or internal limitations may paradoxically lead to superior learning (i.e., the concepts of “starting small” and “less is more”; Elman, 1993; Newport, 1990). In this paper, we explore what conditions might lead to a starting small effect. We report on four artificial grammar learning experiments with human participants. In Experiment 1A, we found an effect...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2018
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2018.08.019